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However, when symptoms occur, often due to the underlying condition rather than the elevated B12 itself, they may include 12 : Acne Headaches Anxiety Irregular heartbeats Trouble falling or staying asleep Nausea Fatigue Dizziness The symptoms of high vitamin B 12 are vague

Animal experiments (in mice) have shown that pharmacologic blockade or genetic deletion of the Y1- and Y5-receptors reduces food intake and weight, with Y1-receptor signaling appearing to be the major mediator of the orexigenic effects of NPY